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The long half-life of I 60 days makes it an exceptionally useful isotope for both in vivo study as well as chemical or biological preliminary investigations in animals. Gebrauchssanleitung distribution of liposomes exhibiting long half-lives in the circulation after vebrauchsanleitung injection. Several core lipids were tested in the donor microemulsions including triolein, canola oil, squalene and seal oil, with seal oil proved to be most effective.
Chylomicrons occurring lipoproteins, triglycerides and cholesterol are naturally transported away from the intestinal tract.
Further research may discover new tissues, healthy or ill, where high concentrations of LDL receptors occur, which may present new areas that are experiencing the samples of the present invention for diagnostic purposes can be used.
The mandyca of formula I as shown in Scheme I by using a combination of conventional preparative steps and recovery methods known to those skilled in the art of organic synthesis, can be produced.
Counsell of the University of Michigan. The kit would further contain instructions describing the appropriate method of use of the components. Preliminary studies showed that I-labeled CI preferably instead of the atheroma in normal arterial tissue enriched [DeGalen bebrauchsanleitung al.
The selected cell line is cultured by standard techniques and the radiolabeled sample is added in the selected carrier vehicle to the culture medium.
In addition, preliminary studies of possible structural and conformational changes after drug loading have been performed by means of various available methods, and showed gebrauchsaneitung there were no significant differences between manfuca LDL and drug-loaded LDL data not shown.
Halogensterylderivate the structural formula 5 can be easily prepared from commercially available cholesterol and sterol derivatives of structural formula 4 using standard reactions known to one skilled in the art, be prepared using a hydroxy group is converted into a halo group, for example by reaction with either thionyl chloride or thionyl bromide.
The reaction mixture was allowed to stir under N 2 for 66 hours, after which it was diluted with CH 2 Cl 2 and then filtered to remove precipitated 1,3-dicyclohexylurea DCU.
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The composition of claim 7, wherein said carrier vehicle is a low-density lipoprotein LDL. Andere auf Gebraucheanleitung basierende Radioimaging-Proben sind ua iodierte Triglyceride in synthetischen Lipidemulsionen, die auf Leberzellen als Ziel ausgerichtet sind.
Manduac competition requires high levels of built in the support sample to ensure that sufficient amounts are delivered to the target cells. Sobald die Austauschreaktion beendet ist, kann die radiomarkierte Verbindung durch ein geeignetes Verfahren, welches leicht von den Fachleuten ermittelt werden kann, gereinigt werden.
A compound according to claim 12 for use in detection of hepatic disease or gebrauchsanletiung detection and localization of tumors in a mammal by radioimaging. A sterol derivative can be one of the sterols commercially available, or it may be a derivative of one of those sterols that can be easily prepared by standard synthetic methods, which are well known to the skilled person.
It is therefore intended that the samples can be used as mabduca diagnostic agent. Developmental changes occurring in the lipids of ram epididymal spermatozoa plasma membrane.
A compound according to claim 6 for use in a radioimaging gebrauchsanleithng methods. The radio imaging is performed as described above for the rabbit model and the model of the transgenic mouse in which the difference in size of the animals made necessary changes.
Die Zellen werden eine geeignete Zeit lang inkubiert, typischerweise etwa 4 Stunden lang, dann wird das Medium entfernt und die Zellen ausgiebig gewaschen, um die externe Radioprobe zu entfernen. Read, write and discuss reviews Chen and Hughes-Fulford, Int. Gebrauchsanleeitung et al, J.
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Examples of suitable carrier vehicles include, but are not limited to, liposomes, low-density lipoprotein LDLmodified LDL and synthetic microemulsions. In general, the dose to be administered unit has a radioactivity of about 0. VAT plus shipping costs. Die radiomarkierte Probe kann durch Injektion in das Tier eingebracht und die Bioverteilung der Probe durch Standardverfahren ermittelt werden [siehe zum Beispiel Xiao et al.
The cholesterol was analyzed enzymatically using a commercially available kit Sigma Chemical Company. As long as I have both hands free. For example, a system based on the sequence of apo B radiolabeled short peptide currently delivering promising results in a clinical multi-center US study [Lees and Lees, Atherosclerosis X, ppElsevier Scientific ].
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Acid anhydrides of the formula 23 are either commercially available or can be prepared by standard reactions known to one skilled in the art are prepared. The cells are lysed and the amount of radiolabeled sample taken from the cells can be determined by measuring the associated with the lysed cells radioactivity. Herstellung von Verbindungen der Formel I I. By combining gebrauchsanletiung appropriate fractions and removing the solvent GIP was obtained as a yellow solid.
The amounts of radiolabeled sample associated with the LDL can be prepared by standard methods, such as are determined maanduca using a gamma counter.
Verfahren zur Zufuhr radiomarkierter Proben A method for supplying radiolabeled samples. Examples include, but are not limited to, liposomes, antibody-bound conjugates, hydrocarbon derivatives of targeted microemulsions of the compound, LDL or chemically modified LDL such as acetylated LDL or oxidized LDL.
Verfahren B method Mannduca. Mehr zu unseren Awards. It has been shown that emulsions of synthetic lipids having a mean particle size in the range nm similar metabolic pathways follow as human chylomicron remnants, probably due to their similar particle size [Weichert et al, J.
In one embodiment of the present invention, harp seal oil is used as the core lipid resulting in high levels of incorporation of the radiolabeled probe into synthetic microemulsions.
Both mp-TdR and dp-IUdR were synthesized by the reaction of either [methyl-3 H] -2′-deoxythymidine or 5-iodo-2′-deoxyuridine with palmitic acid chloride in dimethylacetamide.
A kit for preparing a radiolabeled diagnostic composition for use in radioimaging, comprising the compound according to any one of claimsemulsifying agents and core lipids necessary to prepare a microemulsion, reagents necessary for the radiolabeling of the compound with an appropriate radioisotope of iodine, and an instruction manual.
The reaction can be monitored by thin layer chromatography using a small sample is taken at this point and visualized under ultraviolet light and by autoradiography. The tests carried out in the presence of an excess amount of unlabeled LDL experiments allowed the measurement of non-specific binding of I-LDL to the cells. A compound according to any one of claims 1, 2, 3 or 5, wherein selected I from the group consisting of I, I and I. In unterschiedlichen Zeit- Intervallen werden Blutproben entnommen.
As such, these compounds are included in the interior of the target cells and the gebraichsanleitung they emit is thus localized in the target tissue. Of particular note is the fact that the radio shown pictures not only showed the heavily injured aortic arches, but also other weakly battered areas.