Diagnostic de l’intoxication digitalique et son traitement. Ferrero C. Author affiliations. Clinique universitaire de Médecine Interne, Hôpital Cantonal, Genève . Request PDF on ResearchGate | Intoxication digitalique en période néonatale: rôle de la déshydratation | Background Despite the great progress which has. Request PDF on ResearchGate | Intoxication digitalique massive. Traitement par hémoperfusion sur résine Amberlite XAD 4 | Haemoperfusion over amberlite.

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Correlation of serum magnesium levels and cardiac digitalis intoxication.

Access to the full text of this article requires a subscription. At higher concentrations, they increase the ventricular excitability. Therefore, more calcium is stocked in the sarcoplasmic reticulum, where more calcium is available to the next cellular depolarization and increase in the myocardial contraction Figure 2. National Center for Biotechnology InformationU.

The efficacy and safety of the early immunological treatment by Fab antibodies has modified the therapeutical approach and prognostic [7].

Automatism disturbances To the ventricular floor it may consist of a ventricular extra systoles, more or less frequent, and tachycardia or ventricular fibrillation.

Intoxication Digitalique

Am J Cardiol You may thus request that your data, should it be inaccurate, incomplete, unclear, outdated, not be used or stored, be corrected, clarified, updated or deleted.

Other digestive disorders, abdominal pain such as cramps and diarrhea are sometimes observed reflecting vagal hyperactivity. Recent reports of treatment of massive digoxin overdosage have emphasized the success of medical therapy. Drug interaction Mechanism and consequence of interaction All hypokalemic drugs diuretics, laxatives, corticosteroids, amphotericin B Increased toxicity of digitalis Calcium by injection Increased toxicity of digitalis Phenobarbital phenytoin Decreased plasma concentrations Table 2: Post-countershock arrhythmias in untreated digitaliqque digitalized dogs.


Therapeutic index is narrow increasing the risk of intoxication. Digitalis intoxication is a frequently encountered case in current practice. As per the Law relating to information untoxication and personal integrity, you have the right to oppose art 26 of that lawaccess art 34 of that law and rectify art 36 of that law your personal data. Is pacing still appropriate?

Médecine thérapeutique

The role of magnesium in digitalis toxicity. The repetition of doses is often necessary. The first may make appeal to a diagnosis in the case of a patient treated by digitalis. Clinical manifestations Digestive disorders, neurosensorial disorders and cardiovascular disorders are classically associated in clinical table of the digitalis intoxication. The increase in the intracellular calcium is essential to interaction with the contractile proteins, as well as allowing muscular contraction [2,3].

This report describes a fatal outcome to this problem despite aggressive medical management, including pervenous cardiac pacing and draws attention to deficiencies in current treatment of a serious problem. The treatment is based on the patient risk level. Quick Inventory of Depressive Symptomatology.

Conduction disturbances Can be very early stage with a risk of evolution of severe bradycardia or even an asystole. Associated Data Supplementary Materials. The high cost often limits the access to the hospital centers [7]. Thus, diggitalique digoxinemia may only be interpreted adequately few days after its administration. Despite being very familiar with digitalis, its use always asks for particular attention.


Thus, the heart rate standardizes usually on a period of 30 minutes to 4 hours average delay of 90 minutes following the administration of the fragments of specific digoxin antibodies. Nouv Presse Med The solution should be previously filtered with a 0.

Massive digoxin ingestion. Report of a case and review of currently available therapies.

These electrical changes happen to the T wave and the ST segment with a flattening of the T wave, which becomes negative but remains asymmetric, lowering of the J-point intoxicaion a sub-offset of the ST segment characterized by a cupule to the upper concavity called “cupule digitalis” Figure 3. Cost-effectiveness analysis of the use of digoxin immune Fab ovine for treatment of digoxin toxicity. The ourcome was favorable four hours after administration of the first dose of anti-digoxin antibodies, with a complete reversal of clinical and electrocardiographic signs.