[ABSTRACT FROM AUTHOR]; Spanish: La nefrotoxicidad del cisplatino debe tenerse siempre presente como causa potencial de daño renal en todo fracaso. OBJECTIVE: To review recent advances in the understanding of the mechanisms of cisplatin nephrotoxicity. Factors affecting this toxicity and agents that may. Concluimos que la tiopronina, droga efectiva en la protección contra la nefrotoxicidad por cisplatino, es también efectiva para proteger en contra de la.

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Cypermethrin induced reproductive toxicity in male Wistar rats: Cisplatin; Nephrotoxicity; Tribulus terrestris; Kidneys; Protective effect. Treatment of mice with CP resulted in renal damage, showing a significant decline in the weight of animals treated with CP.

Body cispltino of the mice were recorded initially and at the end of the experimental procedure day 5.

Thus, together with other herbal extracts, T. Users should refer to the original published version of the material for the full abstract. Copyright of Electronic Journal of Biomedicine is the property of Electronic Journal of Biomedicine and its content may not be cispllatino or emailed to multiple sites or posted to a listserv without the copyright holder’s express written permission.

The effect of toxic dose of cisplatin 5. Among its mechanisms of renal functional impairment are: Ten to nefrktoxicidad minutes before use, CP was dissolved in saline in darkness. The kidneys were removed after 4 days of injections, and TUNEL assay on mice’s kidneys were performed. Zygophyllacea against mercuric chloride induced nephrotoxicity in mice, Mus musculus Linn.


Then, fresh fruits of T. Control group received saline, the first experimental group received cisplatin 5.


Different parts of Tribulus terrestris L have been used traditionally in treating a variety of diseases including hypertension and coronary artery diseases, diabetes and hyperlipidemia, as nefrotoxicisad as fungal diseases Sharma et al. The antioxidant activity of T.

Treatment of cisplatin-treated mice with T. Renal tubular apoptosis has been suggested as a mechanism of cisplatin-induced acute kidney injury. Rutin attenuates cisplatin induced renal inflammation and apoptosis by reducing NFkB, TNF-a and caspase-3 expression in wistar rats. Cisplatin nephrotoxicity should always be considered as a potential cause of renal damage in acute renal failure installed in the context of its use. TNFR2-mediated apoptosis and nefrohoxicidad in cisplatin-induced acute renal failure.

Cisplatin cis-diamminedichloroplatinum II CPa most effective chemotherapeutic agent, has been successfully used in treatment of a variety of solid tumors, including ovary, testis, bladder, head and neck, lung, cervix, and endometrium Baek et al.

Extracting method was described previously Keshtmand et al. Tribulus terrestris extract protects against mercury-induced. In conclusion, our previous and present studies indicate that the antioxidant action of T. After 4 days of injections CIS in a dose of 5. Effect of alcoholic extract of Nigella sativa on cisplatin-induced toxicity in rat. The obtained extract weight, 6. CP nephrotoxicity pathological feature, the major adverse effect of CP in approximately one third of patients during chemotherapy in clinic, it has been the cause of renal cell damage, cell death and the loss of renal function or acute renal failure, especially in renal tubules Jiang et al.


Studies on the protective effect of dietary fish oil on cisplatin induced nephrotoxicity in rats. At one day of the experiment an intraperitoneal injection 5. Protective effect of an aphrodisiac herb Tribulus terrestris Linn on cadmium-induced testicular damage. It is an efficient platinum-derived alkylating agent that acts in unspecific phases of the cellular cycle against proliferating and resting cells Lirdi et al.

Flavones mitigate tumor necrosis factor-alpha-induced adhesion molecule upregulation in cultured human endothelial cells: Tribulus terrestris L is also reported to have cooling, diuretic, tonic and aphrodisiac effects Sugunavarman et al.

Differential roles of hydrogen peroxide and hydroxyl radical in cisplatin-induced cell death in renal proximal tubular epithelial cells. Role of Tribulus terrestris Linn. A fruit of traditional Chinese medicine Sugunavarman et cispltino. Experiments were started after one week of adaptation. Salicylate reduces cisplatin nephrotoxicity by inhibition of tumor necrosis factor-alpha.

Effect of saponin from Tribulus terrestris on hyperlipidemia.


Hepatoprotective activity of Tribulus terrestris extract against acetaminophen-induced toxicity in a freshwater fish Oreochromis mossambicus. Collection and preparation of aqueous extract. Cellular and molecular studies on cisplatin-induced apoptotic cell death in rat kidney.

Tribulus terrestris L grows with a wide distribution in tropical and moderate areas, including the US and Mexico, the Mediterranean region, nefrotoxicidd throughout Asia Phillips et al. Treatment of male mice with extract of T.